P&O Cruises, which is part of the Carnival group, will run trips on two ships this summer. The Britannia will cruise from Southampton along the south coast of England for three or four days, and the Iona will travel up to Scotland from Southampton for seven-day trips.
Carnival said that passengers wishing to board would have to have had both vaccination jabs at least a week before departure.
Guests will also have to have travel insurance that “must include medical and repatriation cover” and medical expenses related to Covid-19.
Guests and crew will be expected to respect social distancing rules and wear masks when appropriate.
And should anyone test positive on board, they will be isolated and quarantined.
Paul Ludlow, the president of P&O Cruises, said Carnival expected a government-approved way to prove people had been vaccinated by the summer.
“This is moving at pace,” he said. “We anticipate by the 27 June, which is our first sailing, there will be a government checkmated scheme to prove your vaccination, but at the very least, then of course, a letter from your GP would suffice.
He said that P&O Cruises was “in close conversation with government every day” about travellers being able to prove their Vaccination status.